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Preclinical studies found that treating neuronal, nematode, or rodent AD models with NR resulted in induction of a mitochondrial stress response, including UPR mt and mitophagy, reduced proteotoxic stress, and decreased A accumulation 243

jaundice (yellowing of the eyes or skin)

Some clinical studies have shown that pioglitazone treatment (30 mg/day, P.O for 4 weeks) exhibits antioxidant properties in diabetic patients, as reflected by a decrease in MDA [218, 219]

The acetaminophen infusion is continued by repeating the last IV infusion dose in the protocol (e.g., 100 mg/kg infused over 16 hours on repeat)